Table 4. The associations between IL-1B gene polymorphisms and clinical characteristics of colorectal cancer.

Characteristics	Genotype distributions
rs1143623 Tumor size	GG	GC	CC	GC+CC
≥5cm /<5cm	139/167	73/115	8/24	81/139
OR (95%CI); P-value	1.0 (reference)	0.83(0.57,1.20); 0.310	0.40(0.17,0.92); 0.027	0.70(0.49,1.00); 0.048
CEA
Positive/ Negative	86/220	45/143	11/21	56/164
OR (95%CI); P-value	1.0 (reference)	0.86(0.57,1.31); 0.480	1.34(0.62,2.90); 0.456	0.87(0.59,1.29); 0.499
CA199
Positive/ Negative	85/221	55/133	12/20	67/153
OR (95%CI); P-value	1.0 (reference)	1.08(0.72,1.61); 0.723	1.56(0.73,3.33); 0.247	1.14(0.78,1.67); 0.504
Differentiation
Poor/Well+moderate	43/263	32/156	4/28	36/184
OR (95%CI); P-value	1.0 (reference)	1.26(0.76,2.07); 0.372	0.87(0.29,2.62); 0.809	1.20(0.74,1.94); 0.464
TNM classification
III+IV/I+II	151/154	105/83	9/23	114/106
OR (95%CI); P-value	1.0 (reference)	1.29(0.90,1.86); 0.171	0.40(0.18,0.89); 0.021	1.10(0.78,1.55); 0.601
Adenocarcinoma
Yes/No	176/130	109/79	16/16	125/95
OR (95%CI); P-value	1.0 (reference)	1.02(0.71,1.47); 0.920	0.74(0.36,1.53); 0.414	0.97(0.69,1.38); 0.873
Rectal cancer
Yes/No	239/135	129/59	14/18	143/77
OR (95%CI); P-value	1.0 (reference)	1.23(0.85,1.79); 0.267	0.44(0.21,0.91); 0.024	1.05(0.74,1.49); 0.788
rs1143634	CC	CT	TT	CT+TT
Tumor size
≥5cm /<5cm	159/240	58/61	4/4	62/65
OR (95%CI); P-value	1.0 (reference)	1.44(0.95,2.17); 0.085	1.51(0.37,6.12); 0.562	1.44(0.96,2.15); 0.074
CEA
Positive/ Negative	103/296	37/82	2/6	39/88
OR (95%CI); P-value	1.0 (reference)	1.30(0.83,2.03); 0.255	0.96(0.19,4.82); 0.958	1.27(0.82,1.98); 0.279
CA199
Positive/ Negative	120/279	30/89	1/7	31/96
OR (95%CI); P-value	1.0 (reference)	0.78(0.49,1.25); 0.304	0.33(0.04,2.73); 0.282	0.75(0.48,1.19); 0.219
Differentiation
Poor/Well+moderate	55/344	21/98	3/5	24/103
OR (95%CI); P-value	1.0 (reference)	1.34(0.77,2.32); 0.296	3.75(0.87,16.1); 0.057	1.46(0.86,2.47); 0.160
TNM classification
III+IV/I+II	200/199	58/61	6/2	64/63
OR (95%CI); P-value	1.0 (reference)	0.95(0.63,1.43); 0.791	2.99(0.60,14.97); 0.164	1.01(0.68,1.51); 0.958
Adenocarcinoma
Yes/No	243/156	55/64	2/6	57/70
OR (95%CI); P-value	1.0 (reference)	0.55(0.37,0.83); 0.004	0.21(0.04,1.07); 0.063	0.52(0.35,0.78); <0.001
Rectal cancer
Yes/No	287/112	87/32	7/1	94/33
OR (95%CI); P-value	1.0 (reference)	1.06(0.67-1.68); 0.801	2.73(0.33-22.46); 0.330	1.11(0.71-1.75); 0.647

Bold values are statistically significant (P <0.05)