Table 5. The association of genetic risk score of IL-1B with risk of colorectal cancer.
| Variable | Case (n = 527) | Control (n = 639) | OR (95% CI) | P value | Adjusted OR (95% CI)* | P value | ||||||
| N (%) | N (%) | |||||||||||
| Weighted GRS | ||||||||||||
| First (0) | 227 (43.1%) | 227 (35.5%) | 1 | 1 | ||||||||
| Second (0) | 247 (46.9%) | 307 (51.2%) | 0.81(0.63, 1.03) | 0.087 | 0.81(0.63, 1.03) | 0.090 | ||||||
| Third (0-0.5) | 51 (9.7%) | 101 (15.8%) | 0.51(0.34, 0.74) | <0.001 | 0.51(0.34, 0.74) | <0.001 | ||||||
The genotyping for rs1143623 and rs1143634 was successful in: 526 cases and 637 controls. *Adjusted for sex and age. Bold values are statistically significant (P < 0.05).