Table 1. The relationships between FoxM1 and the clinicopathological variables of patients with ICC (n = 184).
| Category | Subcategory | No | FoxM1 | χ2 | r | P | |
|
High (n = 111) |
Low (n = 73) |
||||||
| Age (years) | ≤ 60 > 60 |
117 67 |
69 (62.2%) 42 (37.8%) |
48 (65.8%) 25 (34.2%) |
0.245 | 0.620 | |
| Gender | Female Male |
85 99 |
46 (41.4%) 65 (58.6%) |
39 (53.4%) 34 (46.6%) |
2.544 | 0.111 | |
| Cirrhosis | No Yes |
138 46 |
82 (73.9%) 29 (26.1%) |
56 (76.7%) 17 (23.3%) |
0.189 | 0.664 | |
| HBsAg | Negative Positive |
133 51 |
75 (67.6%) 36 (32.4%) |
58 (79.5%) 15 (20.5%) |
3.105 | 0.078 | |
| Tumor number | Single Multiple |
121 63 |
60 (54.1%) 51 (45.9%) |
61 (83.6%) 12 (16.4%) |
17.030 | 0.304 | <0.001 |
| Tumor size (cm) | ≤ 5 > 5 |
70 114 |
28 (25.2%) 83 (74.8%) |
42 (57.5%) 31 (42.5%) |
19.503 | 0.326 | <0.001 |
| Capsulation | No Yes |
111 73 |
70 (63.1%) 41 (36.9%) |
41 (56.2%) 32 (43.8%) |
0.876 | 0.349 | |
| Differentiation* | W+M P |
125 59 |
70 (63.1%) 41 (36.9%) |
55 (75.3%) 18 (24.7%) |
3.048 | 0.081 | |
| LNM | No Yes |
111 73 |
55 (49.5%) 56 (50.5%) |
56 (76.7%) 17 (23.3%) |
13.576 | 0.272 | <0.001 |
| Vascular invasion | No Yes |
173 11 |
105 (94.6%) 6 (5.4%) |
68 (93.2%) 5 (6.8%) |
0.163 | 0.686 | |
| TNM† | I+II III+IV |
79 105 |
39 (35.1%) 72 (64.9%) |
40 (54.8%) 33 (45.2%) |
6.947 | 0.194 | 0.008 |
| Resection margin | R0 R1 |
108 76 |
63 (56.8%) 48 (43.2%) |
45 (61.6%) 28 (38.4%) |
0.434 | 0.510 | |
| CEA (IU/L) | ≤ 5.0 > 5.0 |
107 77 |
60 (54.1%) 51 (45.9%) |
47 (64.4%) 26 (35.6%) |
1.931 | 0.165 | |
| CA19-9 (IU/L) | ≤ 35 > 35 |
65 119 |
38 (34.2%) 73 (65.8%) |
27 (37.0%) 46 (63.0%) |
0.146 | 0.702 | |
Abbreviations: FoxM1, Forkhead Box Protein M1; ICC, intrahepatic cholangiocarcinoma; HBsAg, hepatitis B surface antigen; W+M, well + moderately differentiated; P, poorly differentiated; LNM, lymph node metastasis; TNM, tumor node metastasis; CEA, carcinoembryonic antigen; CA19-9, carbohydrate antigen 19-9.
*According to the World Health Organization (WHO) classification of tumors of the digestive system 2010.
† Based on the seventh edition of the cancer staging manual of the American Joint Committee on Cancer.