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. 2018 Dec 21;10(12):4120–4140. doi: 10.18632/aging.101706

Table 3. Enrichment analysis of the effect of FoxM1 expression on related signaling pathways in ICC.

No.       Signaling pathways ES NES Nom P-value FDR q-value
1 PID_MYC_PATHWAY 0.583 1.705 0.016 0.089
2 PID_MYC_ACTIV_PATHWAY 0.601 1.973 0.000 0.009
3 PID_ATM_PATHWAY 0.635 1.871 0.001 0.026
4 PID_ATR_PATHWAY 0.745 2.121 0.000 0.001
5 PID_MET_PATHWAY 0.463 1.464 0.098 0.225
6 KEGG_P53_SIGNALING_PATHWAY 0.612 2.079 0.000 0.003
7 PID_P53_REGULATION_PATHWAY 0.545 1.728 0.004 0.077
8 PID_P53_DOWNSTREAM_PATHWAY 0.472 1.744 0.003 0.071
9 PID_WNT_CANONICAL_PATHWAY 0.574 1.547 0.050 0.172
10 REACTOME_SIGNALING_BY_WNT 0.528 1.555 0.081 0.169
11 REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS 0.537 1.643 0.020 0.129
12 PID_TELOMERASE_PATHWAY 0.476 1.539 0.051 0.170
13 PID_TAP63_PATHWAY 0.471 1.568 0.031 0.165
14 PID_PLK1_PATHWAY 0.791 2.076 0.000 0.003
15 PID_P38_MK2_PATHWAY 0.550 1.524 0.040 0.178
16 PID_FOXO_PATHWAY 0.532 1.561 0.047 0.167
17 PID_BARD1_PATHWAY 0.759 1.983 0.000 0.009

Abbreviations: ES, enrichment Score; NES, normalized enrichment score; Nom P-value, nominal p-value; FDR q-value, false discovery rate q-value. FDR q-value < 0.250 was considered different.