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. 2018 Dec 23;10(12):4152–4165. doi: 10.18632/aging.101713

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Copyright © 2018 Chiou et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Efficacy of HA+PRP treatment on apoptotic signaling and cell cycle modulatory proteins in chondrocytes. (A) Expression of p53, p21 and p-ERK were assessed by western blot after treatment in I+T conditioned medium in the presence of HA, PRP, and HA+PRP. (B) cyclin B, cyclin D, and cyclin E were assessed by western blot after treatment of I+T conditioned medium in the presence of HA, PRP, and HA+PRP. (C) Cell cycles distributions of chondrocytes. Percentages of sub-G1, G1, S, and G2 phases recorded by flow cytometry after treatment of I+T conditioned medium in the presence of HA, PRP, and HA+PRP. *p<0.05, **P<0.01, compared with the value in cells cultured in I+T using student t-test. The results are presented as mean ± S.D. for 15 independent experimental replicates.