Table 7. Serum parameters, cognition and food intake according to ApoE genotype in the elderly.
| Parameters and cognition | ApoE genotype | P value | ||
| E3 (n = 1201) | E2 (n = 249) | E4 (n = 304) | ||
| Serum parameters | ||||
| GLU (mmol/L) | 5.96 (5.85, 6.06) | 5.93 (5.69, 6.17) | 5.86 (5.65, 6.08) | 0.744 |
| TC (mmol/L) | 4.99 (4.93, 5.05) | 4.95 (4.82, 5.07) | 5.10 (4.99, 5.22) | 0.140 |
| TG (mmol/L) | 1.73 (1.65, 1.81) | 2.08 (1.91, 2.26)a | 2.01 (1.85, 2.16)a | 0.000 |
| HDL-C (mmol/L) | 1.42 (1.41, 1.44) | 1.49 (1.45, 1.52)a | 1.42 (1.39, 1.46)b | 0.008 |
| LDL-C (mmol/L) | 2.90 (2.85, 2.95) | 2.65 (2.54, 2.75)a | 2.94 (2.85, 3.04)b | 0.000 |
| a-TOH (μmol/L) | 27.00 (26.54, 27.47) | 28.23 (27.23, 29.25)a | 28.02 (27.12, 28.95)a | 0.025 |
| γ-TOH (μmol/L) | 4.27 (4.18, 4.39) | 4.49 (4.27, 4.73) | 4.51 (4.30, 4.70) | 0.062 |
| a-TOH/TG+TC (μmol/mmol) | 4.09 (4.04, 4.16) | 4.11 (4.04, 4.27) | 4.02 (3.92, 4.13) | 0.270 |
| γ-TOH/TG+TC (μmol/mmol) | 0.65 (0.65, 0.67) | 0.67 (0.62, 0.70) | 0.65 (0.62, 0.67) | 0.708 |
| Retinol (μmol/L) | 1.95 (1.92, 1.99) | 1.92 (1.85, 1.99) | 1.85 (1.78, 1.92)a | 0.020 |
| Retinol/TG+TC (μmol/mmol) | 0.31 (0.31, 0.31) | 0.28 (0.28, 0.31) | 0.28 (0.24, 0.28)a | 0.000 |
| α-TOH/retinol | 15.42 (15.03, 15.81) | 16.23 (15.37, 17.08) | 17.04 (16.27, 17.81)a | 0.001 |
| γ-TOH/retinol | 2.43 (2.36,2.51) | 2.54 (2.37, 2.71) | 2.72 (2.56, 2.87)a | 0.004 |
| Cognition | ||||
| Visual-spatial and executive | 3.74 (3.67, 3.81) | 3.56 (3.41, 3.71) | 3.63 (3.49, 3.76) | 0.062 |
| Naming | 2.90 (2.88, 2.92) | 2.87 (2.82, 2.92) | 2.83 (2.78, 2.88)a | 0.032 |
| Attention | 5.35 (5.29, 5.42) | 5.19 (5.06, 5.32) | 5.30 (5.18, 5.42) | 0.079 |
| Language | 2.05 (2.00, 2.10) | 2.03 (1.92, 2.14) | 1.97 (1.87, 2.07) | 0.414 |
| Abstraction | 1.53 (1.49, 1.57) | 1.46 (1.37, 1.55) | 1.55 (1.47, 1.63) | 0.288 |
| Memory and delayed recall | 2.81 (2.73, 2.90) | 2.66 (2.47, 2.86) | 2.74 (2.56, 2.91) | 0.337 |
| Orientation | 5.84 (5.80, 5.87) | 5.75 (5.67, 5.84) | 5.73 (5.65, 5.81)a | 0.027 |
| MoCA score | 24.37 (24.13, 24.61) | 23.65 (23.11, 24.18)a | 23.87 (23.39, 24.35) | 0.020 |
The data were represented as mean (95% CI) or percentage. General Linear Model (GLM) was used for the comparison of serum parameters and cognitive performance. During the comparison of serum parameter, possible confounding factors including gender, age, BMI, smoking habit, alcohol drinking, usage of antioxidant supplement, physical activity, diabetes and hyperlipidemia were adjusted; During the comparison of cognition, confounding factors including gender, age, BMI, smoking habit, physical activity, alcohol drinking, education level and AD family history were adjusted. MCI, mild cognitive impairment; TC: total cholesterol; TG: triglyceride; LDL-C: low density lipoprotein cholesterol; HDL-C: high density lipoprotein cholesterol; ApoE: Apolipoprotein E; α-TOH: α-tocopherol; γ-TOH: γ-tocopherol; MoCA: Montreal Cognitive Assessment. P < 0.05 was considered to be statistically significant. a: Comparing with ApoE3 subjects, P < 0.05; b: comparing with ApoE2 subjects, P < 0.05.