Table 9. Logistic analysis of ApoE, lipid-adjusted serum α-TOH, retinol status and α-TOH/retinol ratio and the risk of MCI.
| Predictors | B | SE | Wald | Adjusted OR | 95/% CI | P value |
| Independent effect of lipid-adjusted α-TOH | ||||||
| α-TOH/TG+TC Q1 (reference) | - | - | - | 1 | - | - |
| α-TOH/TG+TC Q2 | -0.083 | 0.150 | 0.305 | 0.920 | 0.686, 1.236 | 0.581 |
| α-TOH/TG+TC Q3 | 0.185 | 0.150 | 1.517 | 1.203 | 0.897, 1.613 | 0.218 |
| α-TOH/TG+TC Q4 | 0.323 | 0.147 | 4.841 | 1.382 | 1.036, 1.843 | 0.028 |
| Independent effect of lipid-adjusted retinol | ||||||
| Retinol/TG+TC Q1 (reference) | - | - | - | 1 | - | - |
| Retinol/TG+TC Q2 | -0.284 | 0.144 | 3.903 | 0.753 | 0.568, 0.998 | 0.048 |
| Retinol/TG+TC Q3 | -0.529 | 0.149 | 12.517 | 0.589 | 0.440, 0.790 | 0.000 |
| Retinol/TG+TC Q4 | -1.193 | 0.165 | 56.151 | 0.303 | 0.220, 0.419 | 0.000 |
| Independent effect of α-TOH/retinol ratio | ||||||
| α-TOH/retinol Q1 (reference) | - | - | - | 1 | - | - |
| α-TOH/retinol Q2 | 0.606 | 0.162 | 13.952 | 1.833 | 1.334, 2.519 | 0.000 |
| α-TOH/retinol Q3 | 0.878 | 0.163 | 29.017 | 2.405 | 1.748, 3.310 | 0.000 |
| α-TOH/retinol Q4 | 1.287 | 0.164 | 61.865 | 3.621 | 2.628, 4.990 | 0.000 |
| Synergistic effect of ApoE genotype and lipid-adjusted retinol | ||||||
| ApoE3 × retinol/TG+TC Q1 (reference) - | - | - | 1 | - | - | |
| ApoE2 × retinol/TG+TC Q2 | 0.005 | 0.298 | 0.000 | 1.005 | 0.560, 1.801 | 0.988 |
| ApoE2 × retinol/TG+TC Q3 | 0.488 | 0.259 | 3.564 | 1.629 | 0.982, 2.705 | 0.059 |
| ApoE2 × retinol/TG+TC Q4 | -0.400 | 0.314 | 1.623 | 0.670 | 0.362, 1.240 | 0.203 |
| ApoE4 × retinol/TG+TC Q2 | 0.157 | 0.234 | 0.446 | 1.170 | 0.739, 1.852 | 0.504 |
| ApoE4 × retinol/TG+TC Q3 | -0.551 | 0.305 | 3.263 | 0.576 | 0.317, 1.048 | 0.071 |
| ApoE4 × retinol/TG+TC Q4 | -1.495 | 0.441 | 11.484 | 0.224 | 0.094, 0.532 | 0.001 |
| Synergistic effect of ApoE genotype and lipid-adjusted α-TOH | ||||||
| ApoE3 × α-TOH/TG+TC Q1 (reference) - | - | - | 1 | - | - | |
| ApoE2 × α-TOH/TG+TC Q2 | 0.242 | 0.264 | 0.835 | 1.273 | 0.758, 2.139 | 0.361 |
| ApoE2 × α-TOH/TG+TC Q3 | -0.041 | 0.302 | 0.019 | 0.960 | 0.531, 1.734 | 0.891 |
| ApoE2 × α-TOH/TG+TC Q4 | 0.645 | 0.251 | 6.571 | 1.905 | 1.164, 3.119 | 0.010 |
| ApoE4 × α-TOHl/TG+TC Q2 | -0.615 | 0.275 | 4.997 | 0.540 | 0.315, 0.927 | 0.025 |
| ApoE4 × α-TOH/TG+TC Q3 | 0.022 | 0.266 | 0.007 | 1.022 | 0.607, 1.721 | 0.007 |
| ApoE4 × α-TOH/TG+TC Q4 | 0.191 | 0.261 | 0.531 | 1.210 | 0.725, 2.020 | 0.466 |
| Synergistic effect of ApoE genotype and α-TOH/retinol | ||||||
| ApoE3 × α-TOH/retinol Q1 (reference) - | - | - | 1 | - | - | |
| ApoE2 × α-TOH/retinol Q2 | 0.803 | 0.259 | 9.587 | 2.233 | 1.343, 3.714 | 0.002 |
| ApoE2 × α-TOH/retinol Q3 | 0.534 | 0.300 | 3.174 | 1.706 | 0.948, 3.071 | 0.075 |
| ApoE2 × α-TOH/retinol Q4 | 0.578 | 0.249 | 5.389 | 1.782 | 1.094, 2.902 | 0.020 |
| ApoE4 × α-TOH/retinol Q2 | -0.106 | 0.261 | 0.164 | 0.685 | 0.540, 1.499 | 0.900 |
| ApoE4 × α-TOH/retinol Q3 | -0.203 | 0.281 | 0.523 | 0.469 | 0.471, 1.415 | 0.816 |
| ApoE4 × α-TOH/retinol Q4 | 0.694 | 0.222 | 9.794 | 2.002 | 1.296, 3.093 | 0.002 |
Logistic regression models were created to evaluate the independent and synergistic effects of serum α-TOH, retinol, α-TOH/retinol and ApoE genotype on the risk of MCI. Confounding factors such as age, sex, BMI, education, smoking, alcohol drinking, physical activity levels, diabetes and hyperlipidemia were adjusted during analysis. MCI: mild cognitive impairment; α-TOH: α-tocopherol; ApoE: Apolipoprotein E; SE: standard error; OR: odds ratio; CI: confidence interval; Q: quartile.