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. 2018 Dec 12;10(12):3806–3820. doi: 10.18632/aging.101674

Figure 5.

Figure 5

Overexpression of circEIF6 could enhance autophagy and inhibit apoptosis in the TPC1 and BHT101 cells with cisplatin treatment. (A) Western blot was used to detect the protein of TGF-α, cleaved PPAR, cleaved caspase3, LC3B, p62 expressions. Cleaved PARP and caspase-3 were proteins related to apoptosis; LC3 II/LC3 I ratio and p62 were related to autophagy. *P < 0.05 compared with NC group. (B) GFP-LC3 puncta was less in siCirc-1 or siCirc-2 group and more in circEIF6 group after treated with cisplatin, *P < 0.05 compared with NC group.