Table 1. Correlation between clinicopathological parameters and CREB1/CCAR1/JNK1 expression levels in 200 CRC patients.
| Variables | CREB1 | p | CCAR1 | p | JNK1 | p | |||
| Low(%) | High(%) | Low(%) | High(%) | Low(%) | High(%) | ||||
| Age <60 ≥60 |
23(30.7) 52(69.3) |
39(31.2) 86(68.8) |
0.937 | 15(31.3) 33(68.8) |
47(30.9) 105(69.1) |
0.966 | 22(30.1) 51(69.9) |
40(31.5) 87(68.5) |
0.841 |
| Gender Male Female |
42(56) 33(44) |
72(57.6) 53(42.4) |
0.825 | 30(62.5) 18(37.5) |
84(55.3) 68(44.7) |
0.377 | 42(57.5) 31(42.5) |
72(56.7) 55(43.3) |
0.908 |
| Tumor location Colon Rectum |
52(69.3) 23(30.7) |
90(72.0) 35(28.0) |
0.687 | 30(62.5) 18(37.5) |
112(73.7) 40(26.3) |
0.137 | 52(71.2) 21(28.8) |
90(70.9) 37(29.1) |
0.956 |
| Tumor size <15cm3 ≥15cm3 |
26(34.7) 49(65.3) |
38(30.4) 87(69.6) |
0.531 | 19(39.6) 29(60.4) |
45(29.6) 107(70.4) |
0.196 | 27(37.0) 46(63.0) |
37(29.1) 90(70.9) |
0.252 |
| Differentiation Well& moderate Poor |
54(72.0) 21(28.0) |
101(80.8) 24(19.2) |
0.149 | 38(79.2) 10(20.8) |
117(77.0) 35(23.0) |
0.751 | 56(76.7) 17(23.3) |
99(78.0) 28(22.0) |
0.840 |
| Tumor depth T1-T2 T3-T4 |
8(10.7) 67(89.3) |
18(14.4) 107(85.6) |
0.447 | 11(22.9) 37(77.1) |
15(9.9) 137(90.1) |
0.019 | 13(17.8) 60(82.2) |
13(10.2) 114(89.8) |
0.125 |
| Lymph node invasion Absent Present |
37(49.3) 38(50.7) |
63(50.4) 62(49.6) |
0.884 | 28(58.3) 20(41.7) |
72(47.4) 80(52.6) |
0.185 | 49(67.1) 24(32.9) |
51(40.2) 76(59.8) |
<0.001 |
| Distant metastasis Absent Present |
66(88.0) 9(12.0) |
98(78.4) 27(21.6) |
0.087 | 44(91.7) 4(8.3) |
120(78.9) 32(21.1) |
0.046 | 63(86.3) 10(13.7) |
101(79.5) 26(20.5) |
0.230 |
| pTNM I-II III-IV |
32(42.7) 43(57.3) |
56(44.8) 69(55.2) |
0.769 | 27(56.3) 21(43.8) |
61(40.1) 91(59.9) |
0.0499 | 45(61.6) 28(38.4) |
43(33.9) 84(66.1) |
<0.001 |
| CEA <5µg/l ≥5µg/l |
42(56.0) 33(44.0) |
75(60.0) 50(40.0) |
0.578 | 32(66.7) 16(33.3) |
85(55.9) 67(44.1) |
0.188 | 47(64.4) 26(35.6) |
70(55.1) 57(44.9) |
0.200 |
| CA125 <35U/ml ≥35U/ml |
56(74.7) 19(25.3) |
86(68.8) 39(31.2) |
0.376 | 35(72.9) 13(27.1) |
107(70.4) 45(29.6) |
0.737 | 56(76.7) 17(23.3) |
86(67.7) 41(32.3) |
0.177 |
| CA19-9 <37U/ml ≥37U/ml |
51(68.0) 24(32.0) |
87(69.6) 38(30.4) |
0.813 | 37(77.1) 11(22.9) |
101(66.4) 51(33.6) |
0.165 | 59(80.8) 14(19.2) |
79(62.2) 48(37.8) |
0.006 |
p< 0.05, chi-square test. pTNM: pathological tumor lymph node metastasis classification; CEA: carcinoembryonic antigen; CA125: carbohydrate antigen-125; CA19-9: carbohydrate antigen-19-9.