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. 2018 Dec 4;10(12):3702–3712. doi: 10.18632/aging.101664

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Copyright © 2018 Cai et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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BCAR4 activates GLI2-signaling pathways in PC cells. (A) GLI2 reporter luciferase assay on scrambled or BCAR4 transfected PC346 cells. (B) RT-qPCR on GLI2 downstream genes IL-6, RPS3, TGFβ1 and MUC5AC in scrambled or BCAR4 transfected PC346 cells. (C) GLI2 reporter luciferase assay on scrambled or shBCAR4 transfected DU145 cells. (D) RT-qPCR on GLI2 downstream genes IL-6, RPS3, TGFβ1 and MUC5AC in scrambled or shBCAR4 transfected DU145 cells. (E-H) Correlation between BCAR4 levels and IL-6 (E), RPS3 (F), TGFβ1 (G), and MUC5AC (H) in the 40 CRPC specimens. *p<0.05. N=5 for A-D and N=40 for E-H.