Table 4.
Feature importance
| Feature | LPOCV AUC | CI 95% (Bootstrap) | Statistical Significance | |
|---|---|---|---|---|
| Hopkins Verbal Learning Test Revised, Delayed Recall | 0.812 | 0.722 | 0.887 | x |
| Semantic Interference Test, Retroactive Total Score | 0.810 | 0.715 | 0.888 | x |
| Diagnosis | 0.795 | 0.712 | 0.862 | x |
| Logical Memory, Delayed Recall Score (WMS-IV) | 0.794 | 0.703 | 0.871 | x |
| Logical Memory, Immediate Recall Score (WMS-IV) | 0.789 | 0.688 | 0.868 | x |
| Hopkins Verbal Learning Test Revised, Total Recall | 0.779 | 0.687 | 0.858 | x |
| Semantic Interference Test, Recognition Total Score | 0.778 | 0.664 | 0.868 | x |
| Right entorhinal cortex atrophy (VRS) | 0.761 | 0.654 | 0.853 | x |
| Left hippocampus atrophy (VRS) | 0.732 | 0.629 | 0.827 | x |
| Modified Clinical Dementia Rating Scale, Memory Sum Score | 0.730 | 0.627 | 0.824 | x |
| Right hippocampus atrophy (VRS) | 0.721 | 0.614 | 0.816 | x |
| Delayed Visual Reproduction (WMS-IV) | 0.718 | 0.599 | 0.818 | x |
| Left entorhinal cortex atrophy (VRS) | 0.708 | 0.597 | 0.809 | x |
| Right perirhinal cortex atrophy (VRS) | 0.691 | 0.585 | 0.794 | x |
| Trial Making A, Time (s) | 0.664 | 0.554 | 0.765 | x |
| Trial Making B, Time (s) | 0.659 | 0.543 | 0.766 | x |
| Left perirhinal cortex atrophy (VRS) | 0.647 | 0.538 | 0.753 | x |
| History of stroke/TIA | 0.630 | 0.580 | 0.686 | x |
| Trial Making B, Errors | 0.625 | 0.515 | 0.733 | x |
| Age | 0.622 | 0.501 | 0.732 | x |
| History of coronary bypass/angioplasty | 0.618 | 0.567 | 0.671 | x |
| Body-Mass Index | 0.609 | 0.495 | 0.714 | |
| Block Design Test, Raw Score (WAIS-III) | 0.600 | 0.480 | 0.710 | |
| Education (y) | 0.599 | 0.477 | 0.719 | |
| Digit-Symbol-Coding Score (WAIS-III) | 0.596 | 0.478 | 0.706 | |
| Heart Rate (in beats-per-minute) | 0.584 | 0.463 | 0.697 | |
| Hypercholesterolemia | 0.566 | 0.472 | 0.649 | |
| Similarities Test, raw score (WAIS-III) | 0.563 | 0.446 | 0.676 | |
| Clinical Dementia Rating Scale, Global Score | 0.559 | 0.522 | 0.591 | x |
| Hypertension | 0.541 | 0.437 | 0.640 | |
| History of myocardial infarction | 0.540 | 0.480 | 0.612 | |
| Trial Making A, Errors | 0.526 | 0.454 | 0.581 | |
| Gender | 0.520 | 0.416 | 0.619 | |
| History of tobacco use | 0.516 | 0.461 | 0.548 | |
| Geriatric Depression Scale | 0.512 | 0.409 | 0.615 | |
| Diabetes | 0.509 | 0.426 | 0.569 | |
WAIS-III, Wechsler Adult Intelligence Scale – Version 3; WMS-IV, Weschler Memory Scale – Fourth Edition; VRS, Visual Rating Scale; AUC, area under the receiving operating curve; LPOCV, leave-pair-out cross-validation; CI, confidence interval.