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. Author manuscript; available in PMC: 2019 Nov 15.
Published in final edited form as: Bioorg Med Chem. 2018 Oct 27;26(21):5751–5757. doi: 10.1016/j.bmc.2018.10.028

Table 3.

IC50 values (μM) of potential inhibitors against bacterial and human sialidases using Νeu5Αcα2–3GalβpNP as a substrate.

Sialidases Neu5Ac2en (1) Neu5Ac9N32en (2) (TriazoleNeu5Ac2en)-A (6) (TriazoleNeu5Ac2en)-AdE (7) E-(TriazoleNeu5Ac2en)-AKE (8)
SpNanA 10.0 ± 0.2b 44.3 ± 1.8 100 – 1000 65.6 ± 4.8 100 – 1000
SpNanB > 1000 > 1000 > 1000 > 1000 > 1000
SpNanC > 1000 > 1000 > 1000 > 1000 > 1000
V. cholerae 8.6 ± 1.0a 20 ± 1a 13.5 ± 0.5 10.9 ± 0.8 28.9 ± 3.2
A. ureafaciens 8.1 ± 0.3b 0.72 ± 0.02 100 – 1000 1.87 ± 0.07 100 – 1000
C. perfringens 20 ± 1a 59 ± 5a 100 – 1000 100 – 1000 100 – 1000
BiNanH2 40 ± 2.0b 100 – 1000 > 1000 100 – 1000 > 1000
PmST1 > 1000 > 1000 > 1000 > 1000 > 1000
hNEU2 18 ± 1a 100 – 1000 > 1000 100 – 1000 > 1000
a

Data are from reference 35

b

Data are from reference 40.