Table I.
Odds Ratio Estimates from Logistic Regression Analysis.
| Odds Ratio | p-value | |||
|---|---|---|---|---|
| Ileal Location | ||||
| Boy vs. Girl | 1.04 (0.56,1.92) | 0.9126 | ||
| Young vs. Old* | 0.75 (0.40,1.41) | 0.3748 | ||
| Duration>36 vs. ≤36 | 1.10 (0.60,2.02) | 0.7658 | ||
| CARD15 + vs. − | 2.84 (1.42,5.66) | 0.0031 | ||
| GM-CSF Ab high vs. low | 3.34 (1.80,6.20) | 0.0001 | ||
| Stricturing/Penetrating Behavior | ||||
| Boy vs. Girl | 0.70 (0.37,1.30) | 0.2543 | ||
| Young vs. Old* | 0.76 (0.39,1.48) | 0.4949 | ||
| Duration>36 vs. ≤36 | with | CARD15 + | 0.54 (0.19,1.55) | 0.2492 |
| Duration>36 vs. ≤36 | with | CARD15 − | 2.64 (1.23,5.67) | 0.0143 |
| CARD15 + vs. − | with | Duration > 36 | 0.50 (0.18,1.36) | 0.0914 |
| CARD15 + vs. − | with | Duration ≤ 36 | 2.45 (1.08,5.56) | 0.0952 |
| L1L3 vs. L2 | 2.81 (1.27,6.21) | 0.0106 | ||
| GM-CSF Ab high vs. low | 2.18 (1.14,4.18) | 0.0180 | ||
| Surgery | ||||
| Boy vs. Girl | 0.45 (0.23,0.88) | 0.0187 | ||
| Young vs. Old* | 1.01 (0.50,2.04) | 0.8772 | ||
| Duration>36 vs. ≤36 | with | CARD15 + | 0.51 (0.17,1.56) | 0.2314 |
| Duration>36 vs. ≤36 | with | CARD15 − | 3.20 (1.40,7.32) | 0.0074 |
| CARD15 + vs. − | with | Duration > 36 | 0.47 (0.16,1.34) | 0.0859 |
| CARD15 + vs. − | with | Duration ≤ 36 | 2.93 (1.19,7.20) | 0.0555 |
| L1L3 vs. L2 | 2.76 (1.15,6.60) | 0.0225 | ||
| GM-CSF Ab high vs. low | 2.14 (1.06,4.31) | 0.0340 | ||
*
Young age was defined as age at diagnosis ≤ 10 years; disease duration was defined in months with a cut-off of 36 months tested; CARD15+: carriage of at least one CARD15 SNP; GM-CSF Ab high was defined as ≥ the median value, 1.6 mcg/ml.