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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2018 Oct;11(10):e006558. doi: 10.1161/CIRCEP.118.006558

Figure 7. IKs stabilizes the AP during β-adrenergic stimulation.

Figure 7.

Representative APs from three populations (300 model variants) to demonstrate how the addition of 1 μM isoproterenol (ISO), and phosphorylation of IKs, influences AP variability. (A) baseline conditions no added ISO (B) added ISO (C) added ISO and blocked PKA phosphorylation of IKs. (D) ISO decreases AP variability compared with control. Blocking phosphorylation of IKs under ISO conditions increases APD variability. (E) Calcium perturbation applied on no ISO, ISO, and ISO + IKs-P block APs shows that inhibiting IKs phosphorylation makes the cell more susceptible to arrhythmic activity.