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. 2018 Oct 13;47(1):152–167. doi: 10.1093/nar/gky947

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© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Restoring DNMT3A levels in Dnmt3l KO mESCs partially rescues DNA methylation. (A) Western blots with Myc and DNMT3A antibodies showing the expression of Myc-DNMT3A1 or Myc-DNMT3A2 in stable clones generated in Dnmt3l KO mESCs. Different lanes represent independent clones. (B) Southern blot analysis showing partial recovery of DNA methylation at the major satellite repeats in Myc-DNMT3A1 or Myc-DNMT3A2 stable clones generated in Dnmt3l KO mESCs. (C) Proposed model suggesting that the formation of the DNMT3L–DNMT3A complex (heterotetramers) results in stimulation of DNMT3A activity and maintenance of DNMT3A stability, both contributing to the role of DNMT3L in facilitating DNA methylation.