Figure 6.

Inosine-induced ribosome stalling is position-independent and occurs in multiple tissues. Inosine levels at known editing sites were calculated from brain mRNA-seq data (top). Ribosome profiling data (ribo-seq) were normalized, weighted by editing rate, merged, and centered on the editing site split according to the position of the inosine in the codon (codon pos.1–3). The coverage from position −1000 to +1000 relative−to the editing site is given. For comparison, ribosome-profiling data from interferon-induced fibroblasts was analyzed (bottom). The number of data points used for averaging is reflected by the thickness of the line.