Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 17;47(1):134–151. doi: 10.1093/nar/gky945

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 11. — Knockdown of MCM7 in human fibroblasts does not mimic transcriptional changes upon MCM2 knockdown. (A) Cycling hTert fibroblasts were transfected with siRNAs and ciliation was induced by serum starvation. Afterwards RNAseq was performed. n = 3. (B) Bar graph displaying the number of DEGs upon MCM7 knockdown versus MCM2 knockdown in human fibroblasts. DEGs were classified as linked to cilia or centrosomes as described in the methods section. (C) Pathways changed upon MCM7 knockdown (cut off: ≥1.5-fold up or down). (D) Pie chart showing the percentage of DEGs associated with cilia, centrosomes or both structures according to literature. Only genes with ≥1.5-fold regulation and P < 0.05 were considered. (E) Only 1 of the 15 DEGs linked to cilia has been reported to alter cilium length (shorter cilia upon knockdown).