Table 2.

Effect of ML302F on meropenem MICs for VIM‐1‐expressing enterobacteriaceae

Strain	Meropenem MIC (μg·mL−1)	Meropenem resistant/intermediate/susceptible (clinical strains; EUCASTa)	Meropenem MIC (μg·mL−1) + 10 μg·mL−1 ML302F	Meropenem resistant/intermediate/susceptible (clinical strains; EUCASTa)	Fold difference in MIC
Escherichia coli TOP1O (control)	≤ 0.25		≤ 0.25		0
Klebsiella pneumoniae NCTC 5055 (control)	≤ 0.25		≤ 0.25		0
K. pneumoniae Kpn20	32	R	8	R	4
K. pneumoniae 08Y70	32	R	2	S	16
K. pneumoniae 08Z37	16	R	4	I	4
K. pneumoniae 09A69	32	R	4	I	8
K. pneumoniae 09B51	8	R	1	S	8
K. pneumoniae 09B53	8	R	1	S	8
K. pneumoniae 09B61	32	R	4	I	8
K. pneumoniae 09B76	64	R	32	R	2
K. pneumoniae 09C12	64	R	16	R	4
K. pneumoniae 09C74	256	R	128	R	2
K. pneumoniae 09C77	32	R	4	I	8
K. pneumoniae 09D21	16	R	1	S	16
K. pneumoniae 10D60	16	R	2	S	8
K. pneumoniae 10F53	16	R	2	S	8
K. pneumoniae 10F74	32	R	8	R	4
K. pneumoniae 1‐57	16	R	2	S	8
K. pneumoniae 1‐60	16	R	4	I	4
K. pneumoniae 1‐61	128	R	128	R	0
K. pneumoniae 1‐70	32	R	4	I	8
K. pneumoniae 10I28	16	R	0.5	S	32
E. coli08Y79	8	R	2	S	4
E. coli 09B20	2	S	0.5	S	4
E. coli 09D25	2	S	≤ 0.25	S	≥ 8
E. coli 1‐37	1	S	≤ 0.25	S	≥ 4
E. coli 1‐47	16	R	4	I	4
E. coli 10F75	2	S	2	S	0
E. coli 2‐4	2	S	0.5	S	4

^aEUCAST breakpoints 61: resistant MIC ≥ 8 mg·L⁻¹; susceptible MIC ≤ 2 mg·L⁻¹. (CLSI breakpoints are resistant MIC ≥ 4 mg·L⁻¹; susceptible MIC ≤ 1 mg·L⁻¹ 58).