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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Sex Med Rev. 2018 Nov 30;7(1):84–94. doi: 10.1016/j.sxmr.2018.09.006

Figure 1: Mechanism of SARM signaling.

Figure 1:

Like androgens, SARMs enter the cytoplasm, where they displace the androgen receptor from heat shock proteins. Once bound, they translocate to the nucleus and act as transcription factors by binding androgen response elements (AREs). Depending on the tissue type and regulatory environment of the cell, different co-regulatory proteins help determine and modulate the transcriptional response. HSP = Heat shock protein. AR = Androgen Receptor. ARE = Androgen Response Element.