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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: FEBS J. 2018 Dec 22;286(1):82–109. doi: 10.1111/febs.14728

Figure 8: Chorioamnionitis exposure altered global term neonatal monocyte gene expression both in unstimulated and LPS stimulated conditions.

Figure 8:

A) Principal component analysis of RNA-seq normalized read counts using ggplot2 (http://ggplot.tidyverse.org). B) Clustered pearson correlation of differentially expressed mRNA transcripts using normalized read counts revealed that unstimulated healthy and chorioamnionitis-exposed term neonatal monocytes had distinct transcript expression profiles. U(n=3)=term healthy unstimulated monocytes, CU(n=2)=term chorioamnionitis-exposed unstimulated monocytes. C) Clustered pearson correlation of differentially expressed mRNA transcripts based on normalized read counts showed that LPS stimulated healthy and chorioamnionitis-exposed monocytes had distinct patterns of RNA expression. L(n=3)=term healthy LPS stimulated monocytes, CL(n=3)=term chorioamnionitis-exposed LPS stimulated monocytes. Differentially expressed mRNA transcripts were determined using the edgeR package.