Table 10:
Increased Differentially Bound H3K4me3 | Increased Differential mRNA Transcripts | Comparison Group | Gene | H3K4me3 Peak Location | Differentially Bound H3K4me3 p-value | Differentially Expressed mRNA Transcript p-value |
---|---|---|---|---|---|---|
Healthya | Uc | CUe | STXBP5-AS1 | Promoter | 2.58E-21 | 4E-4 |
Healthya | Ld | CLf | ITGB3BP | Promoter | 3.07E-31 | 0.0019 |
TPGS1 | Promoter | 2.28E-29 | 6.5E-4 | |||
TACSTD2 | Inside gene | 1.06E-26 | 0.0016 | |||
GPSM2 | Inside gene | 2.19E-24 | 0.0013 | |||
LRR1 | Promoter | 8.4E-24 | 0.0025 | |||
RFNG | Promoter | 1.6E-23 | 0.0035 | |||
PIGZ | Upstream | 2.59E-23 | 2.5E-4 | |||
PGM2 | Inside gene | 2.76E-23 | 0.001 | |||
RGS9BP | Promoter | 2.87E-23 | 2E-4 | |||
FRS3 | Upstream | 3.24E-19 | 2E-4 | |||
NAA50 | Inside gene | 6.06E-19 | 0.0034 | |||
ZNF747 | Promoter | 2.15E-18 | 5.2E-4 | |||
IMPACT | Inside gene | 3.95E-18 | 0.0034 | |||
FKBP9 | Promoter | 2.21E-17 | 4.3E-5 | |||
PRRG4 | Promoter | 4.34E-17 | 1.3E-5 | |||
NDC1 | Inside gene | 4.63E-17 | 0.0028 | |||
PKIB | Upstream | 6.33E-17 | 1.2E-5 | |||
RALGAPA2 | Promoter | 8.71E-16 | 9.9E-5 | |||
B4GALT6 | Upstream | 6.67E-15 | 0.0041 | |||
SNX33 | Promoter | 6.68E-15 | 2.3E-4 | |||
KCTD3 | Promoter | 4.24E-13 | 2.5E-4 | |||
TTC12 | Promoter | 5.72E-12 | 3E-5 | |||
MAD2L1 | Promoter | 1.63E-11 | 7.2E-5 | |||
Choriob | CUe | Uc | RASEF | Downstream | 1.1E-6 | 1.4E-4 |
LRRC70 | Downstream | 9.4E-6 | 5.7E-4 | |||
KLHDC9 | Upstream | 1.3E-4 | 8.7E-5 | |||
CFAP46 | Inside gene | 9E-4 | 1.6E-4 | |||
KEL | Upstream | 0.0017 | 1.6E-4 | |||
SARDH | Upstream | 0.0025 | 3.7E-5 | |||
ZNF608 | Downstream | 0.0026 | 3.6E-5 | |||
CLEC1B | Upstream | 0.0045 | 1.7E-4 | |||
MAP9 | Upstream | 0.015 | 2.6E-4 | |||
Choriob | CLf | Ld | LRGUK | Inside gene | 4.1E-9 | 0.0017 |
DNAJC5B | Upstream | 3.6E-8 | 4E-4 | |||
HIBCH | Upstream | 2E-6 | 0.0042 | |||
FOXP3 | Inside gene | 3.1E-6 | 5.5E-4 | |||
ALAS2 | Inside gene | 2.7E-5 | 0.002 | |||
MECOM | Inside gene | 2.8E-5 | 6.9E-4 | |||
ARV1 | Inside gene | 3.9E-5 | 0.0014 | |||
KLHDC9 | Upstream | 1.3E-4 | 3.9E-5 | |||
MRPL45P2 | Downstream | 2E-4 | 1.8E-4 | |||
TRUB1 | Upstream | 2.2E-4 | 7E-5 | |||
CACNA2D2 | Inside gene | 2.3E-4 | 5.3E-4 | |||
EXTL2 | Downstream | 4.8E-4 | 0.0031 | |||
LGR5 | Upstream | 8.9E-4 | 0.0014 | |||
NMNAT2 | Inside gene | 0.0011 | 0.0022 | |||
MIR652 | Downstream | 0.0013 | 8.7E-4 | |||
DMBX1 | Upstream | 0.0025 | 1.3E-4 | |||
DAPK2 | Inside gene | 0.0033 | 5.5E-5 | |||
RASGRF1 | Inside gene | 0.0035 | 4.1E-5 | |||
CEP44 | Upstream | 0.0036 | 0.0015 | |||
CETN3 | Downstream | 0.0043 | 0.0023 | |||
KCNIP4 | Inside gene | 0.005 | 1.4E-4 | |||
CMKLR1 | Upstream | 0.0055 | 2.4E-5 | |||
MDGA1 | Promoter | 0.01 | 0.0023 | |||
TTYH1 | Upstream | 0.01 | 0.0022 | |||
DYNC2H1 | Inside gene | 0.014 | 6.8E-8 | |||
AXIN2 | Downstream | 0.014 | 2.9E-4 | |||
ZNF385C | Upstream | 0.022 | 0.0011 | |||
NCAPH | Downstream | 0.024 | 1E-5 | |||
DET1 | Upstream | 0.035 | 0.0024 | |||
VIL1 | Upstream | 0.035 | 0.0038 | |||
ACADSB | Downstream | 0.036 | 2.2E-4 |
Healthy=term healthy monocytes,
Chorio=term chorioamnionitis-exposed monocytes,
U=term healthy unstimulated,
L=term healthy LPS stimulated,
CU=term chorioamnionitis-exposed unstimulated,
CL=term chorioamnionitis-exposed LPS stimulated