Table 6:

Gene ontology biological pathways enriched for differentially bound H3K4me3

Groups	Increased in Group	GO Term	Term	DBe Genes in Pathway	p-value	FDRf
U30a vs U30Ca,d	U30	None	None	None	None	None
U30a vs U30Ca,d	U30C	None	None	None	None	None
O30b vs O30Cb,d	O30	None	None	None	None	None
O30b vs O30Cb,d	O30C	None	None	None	None	None
Termc vs TermCc,d	Term	0000209	Protein polyubiquitination	77	3.24E-15	6.22E-12
	Term	0043161	Proteasome-mediated ubiquitin-dependent protein catabolic process	78	4.61E-13	8.91E-12
	Term	0006468	Protein phosphorylation	131	2.47E-10	4.77E-7
	Term	0045893	Positive regulation of transcription, DNA-templated	143	4.63E-10	8.94E-7
	Term	0006357	Regulation of transcription from RNA polymerase II promoter	124	3.24E-9	6.26E-6
	Term	0006915	Apoptotic process	150	6.28E-9	1.21E-5
	Term	0016567	Protein ubiquitination	103	2.56E-8	4.95E-5
	Term	0016032	Viral process	88	8.42E-8	1.63E-4
	Term	0098609	Cell-cell adhesion	81	1.42E-7	2.74E-4
	Term	0002223	Stimulatory C-type lectin receptor signaling pathway	40	4.86E-7	9.39E-4
	Term	0018105	Peptidyl-serine phosphorylation	45	5.37E-7	0.001
	Term	0048010	Vascular endothelial growth factor receptor signaling pathway	31	5.9E-7	0.0011
	Term	0045892	Negative regulation of transcription, DNA-templated	127	9.56E-7	0.0018
	Term	0030036	Actin cytoskeleton organization	45	1.83E-6	0.0035
	Term	0015031	Protein transport	104	2.01E-6	0.0039
	Term	0050852	T cell receptor signaling pathway	49	2.53E-6	0.0049
	Term	0042147	Retrograde transport, endosome to Golgi	29	2.61E-6	0.005
	Term	0007050	Cell cycle arrest	47	3.39E-6	0.0065
	Term	0006914	Autophagy	45	3.64E-6	0.007
	Term	0016569	Covalent chromatin modification	40	4.04E-6	0.0078
	Term	0007049	Cell cycle	64	5.31E-6	0.01
	Term	0006897	Endocytosis	46	5.43E-6	0.01
	Term	0038095	Fc-epsilon receptor signaling pathway	55	6E-6	0.012
	Term	0070936	Protein K48-linked ubiquitination	22	7.68E-6	0.015
	Term	0046777	Protein autophosphorylation	52	2.15E-5	0.042
	Term	0016241	Regulation of macroautophagy	20	3.73E-5	0.072
	Term	0043065	Positive regulation of apoptotic process	79	3.75E-5	0.072
	Term	0051301	Cell division	89	4.76E-5	0.092
	Term	0034976	Response to endoplasmic reticulum stress	28	5.11E-5	0.099
Termc vs TermCc,d	TermC	0045944	Positive regulation of transcription from RNA polymerase II promoter	128	7.2E-8	1.35E-4
	TermC	0061337	Cardiac conduction	16	1.39E-6	0.0026
	TermC	0007267	Cell-cell signaling	43	7.61E-6	0.014
U30Ca,d vs O30Cb,d	U30C	None	None	None	None	None
U30Ca,d vs O30Cb,d	O30C	None	None	None	None	None
U30Ca,d vs TermCc,d	U30C	0000122	Negative regulation of transcription from RNA polymerase II promoter	51	4E-6	0.007
	TermC	0045944	Positive regulation of transcription from RNA polymerase II promoter	119	4.92E-6	0.009
O30Cb,d vs TermCc,d	O30C	0000209	Protein polyubiquitination	59	4.02E-13	7.62E-10
	O30C	0006351	Transcription, DNA-templated	321	1.69E-11	3.21E-8
	O30C	0043161	Proteasome-mediated ubiquitin-dependent protein catabolic process	58	1.14E-10	2.16E-7
	O30C	0006357	Regulation of transcription from RNA polymerase II promoter	94	6.17E-9	1.17E-5
	O30C	0016032	Viral process	70	1.39E-8	2.64E-5
	O30C	0098609	Cell-cell adhesion	65	1.82E-8	3.45E-5
	O30C	0006915	Apoptotic process	111	3.26E-8	6.18E-5
	O30C	0006468	Protein phosphorylation	94	3.41E-8	6.46E-5
	O30C	0002223	Stimulatory C-type lectin receptor signaling pathway	34	4.87E-8	9.23E-5
	O30C	0070936	Protein K48-linked ubiquitination	21	7.97E-8	1.51E-4
	O30C	0045944	Positive regulation of transcription from RNA polymerase II promoter	164	1.04E-6	0.002
	O30C	0038095	Fc-epsilon receptor signaling pathway	44	2.02E-6	0.0038
	O30C	0050852	T cell receptor signaling pathway	38	4.37E-6	0.008
	O30C	0000122	Negative regulation of transcription from RNA polymerase II promoter	124	6.06E-6	0.011
	O30C	0007049	Cell cycle	49	7.43E-6	0.014
	O30C	0042147	Retrograde transport, endosome to Golgi	22	2.24E-5	0.042
	O30C	0007050	Cell cycle arrest	35	2.39E-5	0.045
	O30C	0030036	Actin cytoskeleton organization	33	2.64E-5	0.05
	O30C	0051403	Stress-activated MAPK cascade	11	4.61E-5	0.087
O30Cb,d vs TermCc,d	TermC	None	None	None	None	None

^aU30 = under 30 weeks gestation,

^bO30 = 30–36 weeks gestation,

^cTerm = term gestation,

^dC=chorioamnionitis exposure,

^eDB=differentially bound,

^fFDR=false discovery rate