Table 1. Summary of mouse models of NASH and HCC.

Abbreviations: ✓✓: marked expression; ✓: modest expression; X: no expression; ?: not assessed; HFD: high-fat diet; WD: Western Diet; MCD: methionine-and-choline deficient diet; CD: choline-deficient diet; STAM: streptozotocin+HFD-treated mice; DEN: diethylnitrosamine; ob/ob: leptin-deficient mice; db/db: leptin-receptor-deficient mice; SREBP1c Tg: sterol regulatory element-binding protein 1c transgenic mice; Agouti: KK-Ay-a mice; PTEN ko: phosphatase and tensin homologue deleted on chromosome 10 knockout mice; PPARα ko: peroxisome proliferator-activated receptor α knockout mice; AOX ko: acetyl-CoA oxidase deficient mice; MATA1 ko: methionine adenosyl transferase 1A knockout mice; MUP-uPA Tg: mice expressing transiently high amounts of urokinase plasminogen activator in hepatocytes; DIAMOND: isogenic BL6/129 hybrid strain fed an obesogenic WD supplemented by high fructose and sucrose.

	Obesity	Insulin Resistance	Steatosis	Inflammation/ ER Stress	NASH	Fibrosis	p62 Accumulation	HCC
Diet Models
HFD	✓✓	✓✓	✓✓	✓	×	×	×	×
WD	✓✓	✓✓	✓✓	✓	×	×	×	×
MCD	×	×	✓✓	✓	✓✓	✓✓	?	×
CD	×	×	✓✓	✓	✓✓	✓✓	?	×
HFD/fructose	✓✓	✓✓	✓✓	✓✓	✓✓	✓✓	?	✓✓
CD HFD	✓✓	✓✓	✓✓	✓✓	✓✓	✓	?	✓
Toxins/Diet-Based Models
STAM	×	✓✓	✓✓	✓✓	✓✓	✓	?	✓✓
HFD/DEN	✓✓	✓✓	✓✓	✓✓	×	×	✓✓	✓✓
CD HFD/DEN	✓✓	✓✓	✓✓	✓✓	×	×	?	✓✓
Genetic/Diet Models
ob/ob	✓✓	✓✓	✓✓	✓	×	×	?	×
db/db	✓✓	✓✓	✓✓	✓	×	×	?	×
SREBP1c Tg	×	✓✓	✓✓	✓✓	✓✓	✓✓	?	✓
Agouti	✓✓	✓✓	✓✓	✓	×	×	?	×
PTEN ko	×	✓✓	✓✓	✓✓	✓✓	✓✓	?	✓
PPARα ko	×	×	×	✓✓	✓✓	✓✓	?	✓
AOX ko	×	×	×	✓✓	✓✓	×	?	✓
MAT1A ko	×	×	×	✓✓	✓✓	×	?	✓
MUP-uPA Tg	✓✓	✓✓	✓✓	✓✓	✓✓	✓✓	✓✓	✓✓
DIAMOND	✓✓	✓✓	✓✓	✓✓	✓✓	✓✓	?	✓✓