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. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: Hypertension. 2019 Feb;73(2):390–398. doi: 10.1161/HYPERTENSIONAHA.118.12084

Figure 4. Overexpression of GRP78 increases cardiomyocyte hypertrophic growth in vitro.

Figure 4.

A. GRP78 was overexpressed by adenovirus infection in NRVMs. After PE treatment for 24 hours, cells were harvested for immunofluorescent staining of α-done between control and TG groups after.B. GRP78 overexpression in NRVMs led to more profound hypertrophic growth as shown by increase in cardiac cell size. N = 91–93. C. Overexpression of GRP78 led to increase in protein synthesis, assessed by radioactive leucine incorporation assay. N = 6. D. Anf protein level was augmented by GRP78 overexpression in NRVMs after PE treatment. E. Quantification of D showed significant upregulation of Anf protein. N = 9. F. Anf mRNA level was significantly increased by GRP78 overexpression in NRVMs. N = 3–5. *, p < 0.05; **, p < 0.01; ***, p < 0.001.