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. Author manuscript; available in PMC: 2020 Jan 6.
Published in final edited form as: Annu Rev Pharmacol Toxicol. 2018 Sep 14;59:171–189. doi: 10.1146/annurev-pharmtox-010818-021701

Figure 2. A network-based model of posttraumatic stress disorder (PTSD).

Figure 2.

The figure depicts the cortical representations of the salience network (SN; orange and yellow), central executive network (CEN; red), and default mode network (DMN; green). PTSD has been associated with hyperactive SN leading to heightened threat-detection and impaired modulation of the CEN and DMN. In turn, CEN and DMN deficits are associated with disruption in top-control, as well as several PTSD related symptomatology. The figure was adapted with permission from the Emerge Research Program (emerge.care).