Table 2:
Sensitivity and specificity of treponemal assays for diagnosis of current syphilis, all stages (n=262) and for those with without syphilis (n=403).
| Assay | Sensitivity N=262 |
Specificity N=403 |
|---|---|---|
| FTA-ABS | 90.8%* (86.7–94.0) | 98.0% (96.1–99.1) |
| TP-PA | 95.4% (92.1–97.6) | 100% (99.0–100) |
| LIAISON CIA | 96.9% (94.1–98.7) | 94.5% (91.8–96.5) |
| Bioplex MBIA | 96.9% (94.1–98.7) | 96.7% (94.4–98.2) |
| INNO-LIA | 96.9% (94.1–98.7) | 98.5% (96.8–99.5) |
| Centaur CIA | 97.3% (94.6–98.9) | 95.5% (93.0–97.3) |
| TrepSure EIA | 98.5% (96.1–99.6) | 82.6%† (78.4–86.1) |
*
FTA-ABS less sensitive than TP-PA (p=0.038) or other immunoassays (all p<0.001)
†
TrepSure EIA was significantly less specific than all other assays (all p<0.0001)