Table 3:

Sensitivity of treponemal assays for detection of syphilis, by stage (n=262)

Assay	Primary (n=55)	Secondary (n=98)	Early Latent (N=41)	Late Latent (N=68)
FTA-ABS	78.2%* (65.0–88.2)	92.8%* (85.7–97.0)	100% (90.7–100)	92.6% (83.7–97.6)
TP-PA	94.5% (84.9–98.9)	100% (96.2–100)	100% (90.7–100)	86.8%† (76.4–93.8)
Centaur CIA	94.5% (84.9–98.9)	100% (96.2–100)	100% (90.7–100)	94.1 % (85.6–98.4)
TrepSure EIA	94.5% (84.9–98.9)	100% (96.2–100)	100% (90.7–100)	98.5% (92.1–99.9)
LIAISON CIA	96.4% (94.5–98.2)	100% (96.2–100)	97.6% (87.4–99.9)	92.6% (83.7–97.6)
Bioplex MBIA	96.4% (94.5–98.2)	100% (96.2–100)	95.1% (83.8–99.4)	94.1 % (85.6–98.4)
INNO-LIA	96.4% (94.5–98.2)	100% (96.2–100)	100% (90.7–100)	91.1% (81.7–96.7)

^*FTA-ABS was less sensitive than other assays for primary syphilis (all p ≤0.01) and secondary syphilis (p=0.007)

^†TP-PA significantly less sensitive than TrepSure EIA for late latent syphilis (p=0.009), all other comparisons were not statistically significant.