Table 4. DCL64 liposomes incorporated with oligonucleotides did not affect mice renal or hepatic biochemical functions.
| Weeks postinjection |
Treatment | Dose (mg) | BUN (mg/dL) |
Creatinine (mg/dL) | Alanine transferase (%) | Alkaline phosphatase (IU/L) |
|---|---|---|---|---|---|---|
| 6 | Noninjecteda | 0 | 28.2±3.0 | 0.3±0.0 | 129.8±60.7 | 36.2±24.9 |
| 6 | DCL64a | 5 | 26.8±3.4 | 0.3±0.0 | 126.8±73.0 | 37.6±18.0 |
| 6 | Noninjectedb | 0 | 30.8±2.5 | 0.3±0.1 | 68.8±14.1 | 58.8±22.5 |
| 6 | DCL64b | 10 | 29.5±3.5 | 0.3±0.1 | 55.5±12.3 | 88.3±18.5 |
a
Five mice were used.
b
Five mice were used.