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. 2019 Jan 18;12(1):8–15. doi: 10.18240/ijo.2019.01.02

Figure 2. Pedigree with novel compound heterozygous mutation of CYP1B1.

Figure 2

A: Mutated and normal chromatogram of p.V364M; B: Pedigree; C: Mutated and normal chromatogram of p.P350T; D: Multiple sequence alignment of CYP1B1 proteins from 7 species. Arrow indicates the mutated conserved amino acid; E: Protein modeling of CYP1B1 gene along with wild type amino acid residues of Proline 350 and Valine 364; F: Mutated protein model showing p.P350T and p.V364M.