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. 2018 Jul 2;33(1):159–170. doi: 10.1038/s41375-018-0196-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A recursive partitioning model for PFS and OS identified clinical and genomic markers associated with risk. a A recursive partitioning model for PFS based on the inclusion of genetic and clinical predictors, showing the terminal nodes. b Kaplan–Meier curves were generated for PFS for all terminal nodes of the tree. c Nodes with similar outcome profiles were combined to generate three risk groups. Nodes 8 and 18 were combined to designate low-risk patients (green); nodes 11, 19, and 6 were combined to designate intermediate-risk patients (red); nodes 10 and 7 were combined to designate Double-Hit patients (blue). Double-Hit comprised 6.1% of the total patient population and included patients who were either of the following: bi-allelic inactivation of TP53 or ISS stage III with amplification of CKS1B. Significant differences in PFS between the risk groups are identified (P < 0.0001). d As in (c) with OS. e The risk groups identified in (c) were applied to a subset of Total Therapy patients (n = 85) with available genetic data; significantly different PFS outcomes are observed, with especially poor PFS in Double-Hit patients (P < 0.0001). f As in (e) with OS