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. 2018 Jul 2;33(1):159–170. doi: 10.1038/s41375-018-0196-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The sites of TP53 mutation and their Impact on survival. a Schematic of mutations detected in TP53. b Kaplan–Meier survival curve for PFS for complete set (n = 863) of NDMM patients <75 years of age who had SNV and CNV results, and survival data by TP53 bi-allelic, mono-allelic, or wild-type status. Note that this dataset is larger than the n = 784 dataset, since for this analysis, presence of ISS was not required. c OS in the same set of patients (n = 863)