Fig. 2.

Loss of Ldha does not affect tumor initiation, progression or pathology. a Pathology of KrasG12D/p53 induced tumors from HFSCs with and without Ldha deletion appear indistinguishable across tumorigenesis. Scale bars, 200 µm. b Quantification of time to tumor formation (left), the number of tumors formed, or the tumor volume showed no significant difference between Ldha expressing vs. Ldha deleted tumors. Also shown is results from animals where KrasG12D/p53 was generated under the control of the Lgr5CreER, or in independent experiments where chemical carcinogenesis (DMBA/TPA) was carried out. Each bar represents the average across indicated values for n. Shown as mean ± SEM. Paired t test was performed, P < 0.05 shown for each genotype versus wild-type control