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. 2019 Jan 9;10:97. doi: 10.1038/s41467-018-07928-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Biochemical activity of SQLE inhibitors and their inactive analogs. a Structures of inactive analogs, NB-598.ia and Cmpd-4′′.ia. b NB-598 inhibits baculosome-derived SQLE with an IC₅₀ of 63 nM, while the structural analog NB-598.ia has an IC₅₀ of >100 μM (left panel) and Cmpd-4′′ inhibits baculosome-derived SQLE with an IC₅₀ of 69 nM, while the structural analog Cmpd-4′′.ia has an IC₅₀ of >100 μM (right panel). Points and error bars are the mean and standard deviation of triplicate experiments