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. 2019 Jan 9;9:16. doi: 10.1038/s41598-018-37115-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of adiponectin overexpression on muscle regeneration. (A) Overview of the experiment for assessing the effects of adiponectin overexpression on muscle regeneration. (B) Representative H&E staining of tibialis anterior (TA) muscle at 7 days after CTX injection. Scale bars, 200 μm. Myofiber area (%) (myofiber area/total area) was quantified from H&E stains. Residual necrotic region area (%) (necrotic area/total area) was identified and quantified from H&E staining by a method described in Methods. Data are mean ± s.e.m., n = 3 (AII−), n = 6 (AII+), *P < 0.05; **P < 0.01, Tukey’s test. Raw image and identified necrotic region of all sections were in Fig. S3. (C) Immunofluorescent staining of embryonic myosin heavy chain (eMyHC) in WT mice. eMyHC positive myofiber area was quantified and shown in right. (D) mRNA expression of eMyHC, collagen 1a1 (Col1a), and AXIS inhibition protein 2 (Axin2). Data are mean ± s.e.m., n = 5 (day5, APN), n = 6 (others), n.s; not significant; *P < 0.05.