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. 2018 Jul 6;33(1):1–14. doi: 10.1038/s41375-018-0184-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Regional association plot for 14q11.2. a and b show SNPs (red circles) plotted by GWAS P-values (−log₁₀, y-axis) and location (x-axis, GRCh37/hg19). Recombination rate (cM/Mb) light blue line (y-axis). SNP colour denotes linkage disequilibrium with the lead SNP, (r² = 0, white, r² = 1.0, dark red). a Association plot annotated with genes from Gencode v27. Multicolour bar shows B-cell chromatin states from ChomHMM. b Association plot of SNPs within 1 kb of the lead SNP. Blue lines denote transcription factor ChIP-Seq peaks. Black bar, B-cell DNAse hypersensitivity peak