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Synthesis of 5’–aminoacyl–5’–deoxy-nucleosidesulfonamide (47-52).Reagents and conditions: (i) DMK, PTSA, DMP, r.t., 24 h; (ii) thioaceticacid, PPh3, DEAD, THF, 0ºC, 1.5 h; (iii)NH3/MeOH, 0ºC to r.t., overnight; (iv) CH3CN/AcOH/H2O (40:1.5:1 v/v) DCDMH, 1h; (v) NH3, 0ºC to r.t., 1h; (vi) Boc/Cbz-aa-(tBu/Bn)-OSu, DBU, DMF; 6-8 h; (vii) TFA/H2O (5:2 v/v), r.t. 2.5 h;(viii) Pd/C, methanol,HOAc, H2, r.t. overnight. (Source: Modified of Gadakh et al., [67]).
