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Synthesis of 4-substituted-2-(1,2,3)-triazole-1-yl-N6-methyl adenosine analogues (26). Reagents and conditions: (i) CH3NH3+Cl–, Et3N, EtOH; (ii) NH3 (7N) /MeOH; (iii) CuI, (Ph3P)2PdCl2, alkyne, Et3N, DMF; (iv) CuSO4⋅5H2O, sodium ascorbate, L-proline, Na2CO3, H2O/t-BuOH (1:1), 60 ºC; (v) CuSO4⋅5H2O, sodium ascorbate, alkyne, H2O/t-BuOH (3:1), r.t. (Source: Modified from Cosyn et al., [49]).
