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C8-amino-N6-disubstituted adenosine derivatives.
|
Route | Derivative | R1 (N6) | R2 (C8) | |||
|---|---|---|---|---|---|---|---|
| I | 6 | Cyclopentyl | -CH3 | ||||
| 7 | Cyclopentyl | -CH2-CH3 | |||||
| 8 | Cyclopentyl | - (CH2)2-CH3 | |||||
| 9 | Cyclopentyl | - (CH2)3-CH3 | |||||
| 10 | Cyclopentyl | Cyclopentyl | |||||
| II | 11 | -CH3 | Cyclopentyl | ||||
| 12 | -CH2-CH3 | Cyclopentyl | |||||
| 13 | - (CH2)2-CH3 | Cyclopentyl | |||||
| 14 | - (CH2)3-CH3 | Cyclopentyl | |||||
| III | 15 | -H | -CH3 | ||||
| 16 | -H | -CH2-CH3 | |||||
| 17 | -H | - (CH2)2-CH3 | |||||
| 18 | -H | - (CH2)3-CH3 | |||||
| 19 | -H | cyclopentyl | |||||
(Source: Modified from Roelen et al. [48]).
