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. 2018 Nov 8;25(2):235–247. doi: 10.1093/ibd/izy330

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© 2018 Crohn’s & Colitis Foundation. Published by Oxford University Press on behalf of Crohn’s & Colitis Foundation.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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FIGURE 3. — Histone modifications help to maintain homeostasis in the intestinal epithelium. Histone methylation induced by Polycomb repressive complexes are responsible for intestinal stem cell identity and regeneration following epithelial damage, as well as for proliferation of absorptive and secretory precursors in the transit amplifying (TA) compartments within the intestinal crypt. Histone acetylation and deacetylation play important roles in restricting differentiation of absorptive precursors while promoting differentiation of secretory cells. PRC, Polycomb repressive complex; HDAC, Histone deacetylase; TA, transit-amplifying.