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. Author manuscript; available in PMC: 2019 Jan 10.
Published in final edited form as: Trends Biochem Sci. 2018 Jun 29;43(8):593–605. doi: 10.1016/j.tibs.2018.06.005

Figure 3.

Figure 3.

Inositol-requiring enzyme 1 (IRE1)-a is degraded via SEL1L-HRD1 ERAD, a process that depends on HRD1, SEL1L, OS9, and BiP (A). ERAD deficiency results in IRE1α accumulation, leading to its activation under basal conditions (B).