Changes in cardiac structure and function after treatment with a higher dose of TETA (87.6 mg/kg day) for six weeks. (a) to (d) Echocardiographic detection of LVAWd, LVPWd, ESV, and EF; (e) representative gross anatomic changes of the hearts among four groups; and (f) heart weight to body weight ratio. Data are presented as mean ± SD, n = 5–9, *P < 0.05. EF: ejection fraction; ESV: end-systolic volume; HW/BW: heart weight to body weight ratio; LVAWd: left ventricular anterior wall depth; LVPWd: left ventricular posterior wall depth; NS: normal saline; TAC: transverse aortic constriction; TETA: triethylenetetramine. (A color version of this figure is available in the online journal.)