Fig. 7.

Artifact management and adaptive behavior to large current steps. a Top panel: firing rate (logMUA), first 7 s of recording after a large (~ 1 mA) step in the injected current (from ~ − 0.4 mA to ~ 0.6 mA). An adaptation phenomenon is visible. The red and green dashed circles highlight respectively the changes in the MUA baseline and in the amplitude of the Up states during and after the adaptation phase. Bottom panel: the corresponding MUA trace. The arrows mark three artifacts due to three small (< 50 μA) current updates. b Top panel: firing rate (logMUA) illustrating slow oscillations. Bottom panel: spikes in the MUA trace are artifacts due to current updates: the amplitude of the artifacts is proportional to the current jump. Artifacts are removed before computing the MUA trace (top panel) and do not affect the Up state detection. MUA, multiunit activity. Inset, one expanded Up state. Top, log MUA. Bottom, MUA