Table II.
Correlation between myostatin levels and laboratory parameters.
| PCOS | Controls | Whole population | ||||
|---|---|---|---|---|---|---|
| Parameter | r | P-value | r | P-value | r | P-value |
| Age (years) | −0.083 | 0.582 | −0.028 | 0.861 | −0.044 | 0.681 |
| BMI (kg/m2) | 0.019 | 0.899 | −0.138 | 0.384 | −0.063 | 0.557 |
| Waist circumference (cm) | −0.234 | 0.118 | 0.067 | 0.673 | −0.108 | 0.318 |
| FSH (mIU/ml) | 0.037 | 0.809 | 0.099 | 0.532 | 0.083 | 0.444 |
| LH (mIU/ml) | −0.147 | 0.329 | 0.117 | 0.461 | −0.045 | 0.676 |
| Estradiol (pg/ml) | −0.048 | 0.752 | −0.034 | 0.831 | −0.024 | 0.822 |
| Prolactin (ng/ml) | −0.198 | 0.188 | −0.014 | 0.932 | −0.066 | 0.540 |
| TSH (µIU/ml) | 0.113 | 0.453 | 0.141 | 0.372 | 0.112 | 0.297 |
| HDL-C (mg/dl) | 0.094 | 0.533 | −0.007 | 0.965 | 0.051 | 0.638 |
| LDL-C (mg/dl) | −0.362 | 0.018a | −0.217 | 0.148 | −0.254 | 0.016a |
| Triglyceride (mg/dl) | 0.067 | 0.659 | 0.071 | 0.657 | 0.066 | 0.542 |
| Total cholesterol (nmol/l) | −0.028 | 0.855 | −0.248 | 0.114 | −0.184 | 0.087 |
| DHEA-S (µg/dl) | 0.060 | 0.693 | 0.064 | 0.689 | 0.045 | 0.680 |
| Total testosterone (nmol/l) | −0.016 | 0.916 | 0.041 | 0.798 | 0.015 | 0.891 |
| SHBG (nmol/l) | −0.204 | 0.175 | −0.175 | 0.268 | −0.193 | 0.071 |
| FAI (%) | 0.050 | 0.743 | 0.196 | 0.214 | 0.104 | 0.335 |
| FBG (mg/dl) | −0.413 | 0.004 | 0.067 | 0.673 | −0.179 | 0.094 |
| Insulin (µIU/ml) | −0.053 | 0.728 | 0.270 | 0.084 | 0.065 | 0.544 |
| HOMA-IR | −0.130 | 0.390 | 0.216 | 0.169 | 0.030 | 0.783 |
| hs-CRP (mg/l) | 0.051 | 0.736 | 0.053 | 0.738 | 0.058 | 0.589 |
| Albumin (g/dl) | −0.273 | 0.067 | 0.050 | 0.751 | 0.008 | 0.940 |
| Neutrophils (×103/µl) | −0.122 | 0.419 | −0.018 | 0.909 | −0.067 | 0.536 |
| Lymphocytes (×103/µl) | 0.007 | 0.964 | −0.150 | 0.343 | −0.100 | 0.353 |
| Monocytes (×103/µl) | −0.081 | 0.591 | −0.168 | 0.288 | −0.138 | 0.199 |
| Platelets (×103/µl) | −0.153 | 0.311 | −0.082 | 0.604 | −0.088 | 0.416 |
Pearson's and non-parametric Spearman correlation analysis was performed.
a
P<0.05. r, correlation coefficient; PCOS, polycystic ovary syndrome; BMI, body mass index; FSH, follicle-stimulating hormone; LH, luteinizing hormone; TSH, thyroid-stimulating hormone; HDL-C, high-density-lipoprotein cholesterol; LDL-C, low-density-lipoprotein cholesterol; DHEA-S, dehydroepiandrosterone sulfate; SHBG, sex hormone-binding globulin; FAI, free androgen index; FBG, fasting blood glucose; HOMA-IR, homeostasis model assessment insulin resistance index; hs-CRP, high-sensitivity C-reactive protein.