Table 2.

Definition of laminitis categories based on the duration of clinical signs, gross pathology, and histopathology

Pathology Category	Duration (days)	Gross Score	Laminitis Histopathology
Non-Laminitic	0	1	–
Sub-Clinical	0	1	+
Moderate	> 7	2 or 3	+
Severe	> 7	4	+

legend: Laminitis pathology categories for limbs from cases and control horses, based on the duration of clinical signs of laminitis in days, gross pathology severity score (1–4), and presence or absence of histological lesions consistent with laminitis, as described in detail in Methods. See Table A1 (see Additional file 1) for duration and gross score, and Tables A4-A8 (see Additional files 4, 5, 6, 7 and 8) for qualitative scoring used to determine presence or absence of histological lesions consistent with laminitis for each limb