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. 2019 Jan 9;17:15. doi: 10.1186/s12967-018-1751-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Comparison of 0 → 5 and 5 → 10 DNA methylation changes. a Venn diagrams illustrating the overlap between 0 → 5 and 5 → 10 dmCpGs (the results of a Fisher’s test for over-enrichment of the overlap is shown). b Plots illustrating the age-dependent change in β-value for 4 examples of dmCpGs common to both 0 → 5 and 5 → 10 (see Additional file 12: Figure S4 for all 36 CpG plots). c Network of gene–enhancer interactions observed between dmCpGs mapped to enhancer elements in blood tissue and cell types and associated genes. The number of connections between nodes reflects the mapping of a dmCpG to enhancers in more than one track