Table 2.
Selection of differentially expressed genes in S. aureus in co-culture versus mono-culture
| gene | FCa | annotation | functional category |
|---|---|---|---|
| Up-regulated genes | |||
| pyrP | 255.62 | uracil permease | metabolism |
| pyrC | 126.35 | dihydroorotase | metabolism |
| pyrB | 94.35 | aspartate transcarbamoylase | metabolism |
| pyrA | 94.34 | Carbamoyl-phosphate synthase small chain | metabolism |
| carB | 56.66 | Carbamoyl-phosphate synthase large chain | metabolism |
| pyrR | 54.32 | Bifunctional protein PyrR | metabolism |
| pyrF | 37.64 | Orotidine 5′-phosphate decarboxylase | metabolism |
| pyrE | 29.69 | Orotate phosphoribosyltransferase | metabolism |
| pyrD | 24.95 | Dihydroorotate dehydrogenase (quinone) | metabolism |
| argG | 15.30 | Argininosuccinate synthase | aa metabolism |
| argH | 12.49 | Argininosuccinate lyase | aa metabolism |
| adhE | 7.64 | alcohol dehydrogenase | metabolism |
| NWMN_1896 | 6.34 | phage major capsid protein NM1 | phage |
| gapR | 6.00 | glycolytic gap-pgk-tpi-pgm-eno operon | metabolism |
| ndhF | 5.88 | NADH:menaquinone oxidoreductase (subunit 5) | metabolism |
| pgk | 5.81 | glycolytic gap-pgk-tpi-pgm-eno operon | metabolism |
| tpiA | 5.67 | glycolytic gap-pgk-tpi-pgm-eno operon | metabolism |
| gapA | 5.57 | glycolytic gap-pgk-tpi-pgm-eno operon | metabolism |
| pgm | 5.49 | glycolytic gap-pgk-tpi-pgm-eno operon | metabolism |
| porA | 5.18 | Pyruvate flavodoxin ferredoxin oxidoreductase | metabolism |
| purA | 4.42 | Adenylosuccinate synthetase | meatbolism |
| NWMN_0997 | 3.26 | phage NM2 | phage |
| adh1 | 3.17 | Alcohol dehydrogenase | metabolism |
| scdA | 2.72 | Iron-sulfur cluster repair protein ScdA | metabolism |
| NWMN_1213 | 2.37 | Glutathione peroxidase | metabolism |
| sodA | 2.18 | Superoxide dismutase | metabolism |
| hpt | 2.01 | Hypoxanthine phosphoribosyltransferase | metabolism |
| Down-regulated genes | |||
| arcB | −35.81 | Ornithine carbamoyltransferase | aa metabolism |
| arcA | −26.57 | Arginine deiminase | aa metabolism |
| arcD | −22.97 | Arginine/ornithine antiporter | aa metabolism |
| cidA | −16.67 | Holin-like protein CidA | cell envelope |
| alsD | −14.89 | Alpha-acetolactate decarboxylase | metabolism |
| alsS | −10.50 | Alpha-acetolactate synthase | metabolism |
| splD | −10.50 | Serine protease SplD | virulence |
| putA | −6.94 | Proline dehygrogenase | metabolism |
| pflB | −5.92 | Formate acetyltransferase | metabolism |
| capJ | −5.60 | Capsular polysaccharide biosynthesis | cell envelope |
| capI | −5.59 | Capsular polysaccharide biosynthesis | cell envelope |
| trpD | −5.57 | Anthranilate phosphoribosyltransferase | aa metabolism |
| lukE | −5.52 | leukotoxin LukE | virulence |
| glpF | −5.47 | glycerol uptake facilitator | transport |
| capN | −5.46 | Capsular polysaccharide biosynthesis | cell envelope |
| hisB | −5.39 | Imidazoleglycerol-phosphate dehydratas | metabolism |
| trpE | −5.31 | Anthranilate synthase component I | aa metabolism |
| capL | −5.25 | Capsular polysaccharide biosynthesis | cell envelope |
| capO | −4.94 | Capsular polysaccharide biosynthesis | cell envelope |
| splA | −3.91 | Serine protease SplA | virulence |
| splB | −3.44 | Serine protease SplB | virulence |
| sarV | −3.47 | Staphylococcal accessory regulator | signal transduction |
| murP | −3.04 | sucrose-specific PTS transporter IIBC component | transport |
| lytN | −2.35 | cell wall hydrolase | cell envelope |
| sarA | −2.30 | Global transcriptional regulator | signal transduction |
| sarR | −2.20 | Staphylococcal accessory regulator | signal transduction |
| purR | −2.18 | Pur operon repressor | metabolism |
| gltD | −2.11 | Glutamate synthase, small subunit | N-metabolism |
| gltB | −2.10 | Glutamate synthase, large subunit | N-metabolism |
aFC fold change; values are the average of three replicates after normalization