Table 2.
Cox Proportional Hazard Model of Disease Specific Survival in Oropharyngeal Cancer Patients
| Covariate | Univariate | Multivariate | ||
|---|---|---|---|---|
| Hazard Ratio (95% CI) | P | Hazard Ratio (95% CI) | P | |
| Age | 1.05 (1.03–1.08) | < 0.001 | 1.04 (1.01–1.07) | 0.01 |
| Gender | 1.41 (0.81–2.47) | 0.22 | 1.14 (0.59–2.20) | 0.69 |
| P16 positive | 0.30 (0.18–0.51) | < 0.001 | 0.36 (0.19–0.68) | 0.001 |
| Smoking 10 py | 2.73 (1.35–5.54) | 0.005 | 1.90 (0.87–4.13) + EGFR 2.17 (1.06–4.46) - EGFR |
0.1 0.003 |
| Smoking 20 py | 2.67 (1.58–4.52) | < 0.001 | 1.52 (0.81–2.87) + EGFR 1.69 (0.97–2.95)- EGFR |
0.2 0.06 |
| EGFR total | 2.28 (1.14–4.54) | 0.02 | 1.51 (0.72–3.15) + smoking 1.96 (1.0–3.91) - smoking |
0.28 0.05 |
| TNM stage IV (vs III) | 1.07 (0.61–1.89) | 0.81 | 1.07 (0.56–2.04) | |
Multivariate models were generated using age as a continuous variable, and gender, smoking, p16 positivity, total EGFR levels and TNM stage as categorical covariates. Separate models were generated including: 1) all variables listed, 2) a model excluding smoking as shown for EGFR total and 3) models excluding EGFR for smoking status