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. 2019 Jan 10;14:13. doi: 10.1186/s13023-018-0983-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Expression of neuronal specific markers by aiNSC. Several early neuronal markers were expressed by the aiNSC simulation. Namely, CK18/K18, MAP2, TUBB3, DCX/Doublecortin, CK8/K8, TH, ChAT, and OLIG2 were all expressed in the aiNSC simulation. The probability that 16 of the 17 (94.12%) neuronal marker expression outcomes were accurately predicted by chance alone using the binomial test is (p = 0.0075). Data are representative of three independent simulation experiments; error bars indicate ± SEM