Table 3.
“Within Patient” analysis: Association between changes in gene signature and changes in disease activity between two visits from the same persona,b
| IFN M1.2 | IFN M3.4 | IFN M5.12 | BAFF | LDG | Plasma Cell | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Estimate (95% CI) |
p value | Estimate (95% CI) |
p value | Estimate (95% CI) |
p value | Estimate (95%CI) |
p value | Estimate (95% CI) |
p value | Estimate (95% CI) |
p value | |
| PGA | 0.11 (− 0.03, 0.25) |
0.12 | 0.09 (− 0.02, 0.19) |
0.10 | 0.05 (− 0.04, 0.15) |
0.28 | 0.02 (− 0.06, 0.10) |
0.64 | − 0.06 (− 0.17, 0.05) |
0.29 | 0.07 (− 0.01, 0.15) |
0.074 |
| SLEDAI | 0.35 (− 0.26, 0.97) |
0.26 | 0.31 (−0.15, 0.77) |
0.18 | 0.29 (−0.13, 0,71) |
0.17 | 0.16 (−0.20, 0.53) |
0.38 | −0.06 (− 0.54, 0.42) |
0.80 |
0.45
(0.10, 0.80) |
0.011 |
| SLEDAI Vascular | 0.02 (−0.01, 0.06) |
0.25 | 0.01 (−0.01, 0.04) |
0.34 | 0.01 (−0.02, 0.03) |
0.45 | 0.01 (−0.01, 0.03) |
0.33 | −0.00 (− 0.03, 0.03) |
0.97 | 0.01 (− 0.01, 0.03) |
0.27 |
| SLEDAI MUSCULOSKELETAL | 0.02 (−0.03, 0.07) |
0.36 | 0.02 (−0.02, 0.06) |
0.34 | 0.01 (−0.02, 0.05) |
0.41 | 0.01 (−0.02, 0.04) |
0.58 | −0.01 (− 0.05, 0.03) |
0.65 | 0.01 (− 0.02, 0.04) |
0.65 |
| SLEDAI Renal | 0.03 (−0.06, 0.11) |
0.54 | 0.03 (−0.03, 0.09) |
0.36 | 0.05 (−0.01, 0.11) |
0.078 | 0.02 (−0.03, 0.07) |
0.36 | 0.03 (−0.03, 0.10) |
0.33 | 0.02 (−0.03, 0.06) |
0.54 |
| SLEDAI Skin | −0.03 (− 0.11, 0.06) |
0.53 | − 0.00 (− 0.07, 0.06) |
0.88 | −0.02 (− 0.07, 0.04) |
0.60 | −0.04 (− 0.09, 0.01) |
0.15 | 0.03 (− 0.03, 0.10) |
0.31 | 0.02 (− 0.02, 0.07) |
0.31 |
| SLEDAI Hematologic |
−0.04
(− 0.07, − 0.01) |
0.0095 |
−0.03
(− 0.05, − 0.01) |
0.0096 |
−0.03
(− 0.05, − 0.01) |
0.014 |
−0.02
(− 0.04, − 0.00) |
0.028 |
−0.03
(− 0.06, − 0.01) |
0.0060 | 0.01 (− 0.02, 0.03) |
0.36 |
| SLEDAI Immunology | 0.00 (− 0.08, 0.09) |
0.92 | 0.00 (− 0.06, 0.06) |
0.96 | −0.02 (− 0.08, 0.03) |
0.42 | 0.00 (− 0.05, 0.05) |
0.97 |
−0.08
(− 0.14, − 0.01) |
0.026 |
0.09
(0.04, 0.14) |
0.0002 |
| Urine Protein Creatinine Ratio | 0.06 (−0.07, 0.19) |
0.36 | 0.05 (−0.05, 0.15) |
0.32 | 0.05 (−0.04, 0.13) |
0.31 | 0.06 (−0.02, 0.14) |
0.12 | −0.04 (− 0.14, 0.06) |
0.44 | 0.05 (− 0.02, 0.13) |
0.17 |
| Log Anti-dsDNA | 0.05 (−0.16, 0.25) |
0.65 | 0.05 (−0.10, 0.20) |
0.52 | −0.01 (− 0.15, 0.13) |
0.94 | 0.03 (− 0.09, 0.15) |
0.65 | −0.05 (− 0.21, 0.11) |
0.56 |
0.20
(0.08, 0.32) |
0.0008 |
| C3 | 1.28 (− 3.56, 6.11) |
0.60 | 1.99 (− 1.66, 5.63) |
0.28 | 2.57 (−0.75, 5.88) |
0.13 | −0.20 (− 3.07, 2.67) |
0.89 |
5.71
(1.90, 9.51) |
0.0034 |
−3.60
(− 6.38, − 0.81) |
0.011 |
| C4 | 0.73 (−0.35, 1.82) |
0.18 | 0.52 (−0.30, 1.34) |
0.21 | 0.57 (−0.18, 1.31) |
0.14 | 0.18 (−0.47, 0.83) |
0.58 |
1.05
(0.19, 1.90) |
0.017 |
−1.39
(−2.01, −0.77) |
< 0.0001 |
| ESR | 2.19 (− 1.17, 5.55) |
0.20 | 2.25 (−0.28, 4.78) |
0.082 |
2.43
(0.13, 4.73) |
0.039 | −0.14 (−2.15, 1.87) |
0.89 | 2.05 (−0.63, 4.73) |
0.13 |
3.75
(1.81, 5.70) |
0.0002 |
aThe entries in the table represent the expected change in disease activity measure per 1 standard deviation change in the gene signature. Bolded enteries had p-values less than 0.05
bAll the associations are adjusted for prednisone use, age, sex and race