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. 2019 Jan 9;13:2. doi: 10.1186/s13036-018-0134-3

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Growth factors and nutrients are more capable of promoting follicle growth when the structure is cultured in 3D (b) versus in 2D culture (a), especially given the complex crosstalk between cells within the follicle (c)